Curcumin is the active anti-inflammatory agent found in the spice turmeric. It has been shown to inhibit the activity of the 5-lipoxygenase and cyclooxygenase enzymes, blocking the synthesis of pro-inflammatory eicosanoids (PG-2, LTB-4).

Curcumin is as effective as a powerful anti-inflammatory drug (phenylbutazone) in reducing pain, swelling and stiffness in rheumatoid arthritis patients. It has also been shown to be effective in the treatment of post surgical inflammation. Studies indicate that curcumin can lower histamine levels and is a potent antioxidant. These factors may also contribute to its anti-inflammatory capabilities.

Boswellia - In clinical studies, the gum resin of the boswellia tree (yielding 70 percent boswellic acids) has been shown to improve symptoms in patients with osteoarthritis, and rheumatoid arthritis. Ind J Med Res 1971; 50:1289-95. Research indicates that boswellic acids inhibit the 5-- lipoxygenase enzyme in white blood cells. As a singular agent, the usual dosage is 150mg, one to three times per day. (Again, lower doses are effective when combined with other natural anti-inflammatory agents.) Boswellia appears to have no important side-effects or drug-- nutrient interactions of concern. . J Nat Prod Aug 2000; 63(8):1058-1061; Phytomed 1996; 3:91-94. Boswellia can switch off key cell signalers and pro-inflammatory mediators known as cytokines in the inflammatory cascade.

Clinical Trials :
National Institutes of Health - Clinical trials Registry
Colon polyp Chemoprevention